CHE

Quantitative safety analysis, applied to chemical processing: fire and explosion hazards, electrostatic hazards, source and dispersion models, relief requirements, quantitative risk assessment, accident case studies.

Covers new technologies that drive new bioproducts and bioprocesses in the pharmaceutical industry. Includes regulatory harmonization, global access to medicines, elements of global supply chain management and risk based quality and marketing approaches that differ across products and countries.

Project based learning experience; three key areas; past discoveries that shaped the industry and its footprint; today's technology and the sustainability issues it faces; future directions based on green chemistry, and bioproduced feedstocks. Industry expert guest lecturers. Industrial site visits.

The causes, effects and control of air pollution, emphasizing fundamental mechanisms: chemistry of pollutant generation, meterorology and atmospheric dispersion, sampling and analysis, data interpretation, theory underlying control systems.

Principles of polymer science: nature and structure of organic high-polymers, polymerization reactions, physical and chemical properties, mechanical testing, viscoelasticity, flow and processing applications.

Techniques for economic evaluation of projects and processes; time value of money, return on investment, cost estimation of processes, alternative project evaluations, economic balances and optimization.

Design of facilities for the pharmaceutical and bioprocess industries. Equipment selection, economics, team work, and presentations.

Analysis of industrial waste disposal: sources of industrial wastes, disposal using physical, chemical and biological processes, overview of governmental regulations to prevent pollution.

Topics of current interest in chemical engineering, (to be announced in advance of offering).

Provide introduction to existing and emerging energy storage methods and their criticality to utilizing renewable sources for the production of electricity and potable water in different geographies and economic regions of the world. Course Requirement: Basic background at undergraduate level in physical sciences.

Survey of biomass resources and utilization for the production of bio-based products, including energy, chemicals, and transportation fuels. Life cycle analysis and technoeconomic analysis for addressing the sustainability/environmental aspects and the economic feasibility of biomass production and utilization. Senior Engineers or Grad Science with Instructor's Permission.

Properties and classes of nanomaterials, solid state physics semiconductors, characterization techniques, catalysis for energy transformations, fuel cells, batteries, solar cells, biofuels, hydrocarbons and hydrogen.

Overview of homogeneous and heterogeneous chemical kinetics, thermodynamic effects on rate laws and reactor behavior, reactor design for simple and complex reactions, mass and energy balances over reactors, transient and non-ideal reactor behavior.

In-depth look at homogeneous and especially heterogeneous kinetics and catalysis, collision and transition state theories, analysis of reaction sequences, rate laws from experimental data, and heat and mass transport effects on catalyst and reactor performance.

The design of chemical processes: synthesizing a process, organizing material and energy balances for solution, iterative convergence techniques, cost estimation and economic analysis, process improvemment, energy conservation, interaction of process units, process control, designing for safety.

Unified study of momentum, heat, and mass transport with emphasis on theory and applications of fluid dynamics and mass transfer. Underlying physical laws, mathematical representation of transport laws, transport analogies.

Theory and applications of fluid dynamics: continuity equation, equation of motion, ideal fluid flow, laminar viscous flow, boundary layer flow, turbulent flow.

Mechanisms, theory and applications of heat transfer by conduction, convection and radiation.

Distillation processes, from the equilibrium-stage point of view: separation factors, phase equilibrium relationships, analysis of steady state processes such as flash vaporization, binary, multicomponent and azeotropic distillations, batch distillation.

Separation processes other than distillation, from the equilibrium-stage point of view: gas absorption, extraction, leaching, adsorption, filtration and sedimentation, ultracentrifugation, evaporation.

Advanced concepts of thermodynamics: equations of state, physical and chemical equilibrium, estimation of thermodynamic properties.

Mathematical techniques for analyzing chemical engineering problems: development of mathematical models of physical and chemical problems, time dependent and position dependent models, solution of model equations by numerical techniques, computer applications

Materials for use in medicine and in/on the body, material bulk and surface properties, biological responses to materials, applications, manufacturing processes, cost, sterilization, packaging and regulatory issues. Drug delivery mechanisms, issues, and modeling.

Basics of biochemistry, microbiology, cell biology and molecular biology, as applied to bioproduct formation; enzyme kinetics, immobilized enzymes, diffusion limitations, immobilized enzyme reactors; cell growth kinetics, batch and continuous fermentor operation, bioreactor operation; sterilization, oxygen transfer and scaleup.

Fedbatch, continuous, immobilized-cell and other advanced bioreactors; bioreactor monitoring and control; design and operation of downstream processes, including cell disruption, filtration, extraction, chromatography; facility design; validation and regulatory issues.

An introduction to molecular genetics, genomic editing techniques, and a survey of recent successful gene and cell therapies in the clinic.

Advanced concepts of protein structure, stability, and activity applied to the modification and improvement of proteins and enzymes; along with computer simulations of protein structure and activity.

Technical approaches for converting biomass to energy, fuels, and useful chemicals. New advances, current challenges, industrial applications, important research areas discussed.

MATLAB-based modeling and analysis approaches for drug target identification: introduction to systems biology, biological reaction networks, model construction and parameter estimation, sensitivity analysis, metabolic modeling, pathway network analysis, pharmacokinetic modeling, biological data analysis, and systems biology approaches for personalized medicine.

This course may be taken twice by graduate students.